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Issue 23, 2016
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Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V

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Abstract

This report highlights the discovery of a new polymorph of the anticonvulsant drug phenobarbital (PB) using polymer-induced heteronucleation (PIHn) and unravelling the crystal structure of the elusive form V. Both forms are characterized by structural, thermal and VT-Raman spectroscopy methods to elucidate phase transformation behavior and shed light on stability relationships.

Graphical abstract: Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V

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Publication details

The article was received on 30 Jan 2016, accepted on 25 Feb 2016 and first published on 25 Feb 2016


Article type: Communication
DOI: 10.1039/C6CC00959J
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 4389-4392
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    Polymorphism in phenobarbital: discovery of a new polymorph and crystal structure of elusive form V

    S. Roy, N. R. Goud and A. J. Matzger, Chem. Commun., 2016, 52, 4389
    DOI: 10.1039/C6CC00959J

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