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Issue 24, 2016
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Photoactivatable cytotoxic agents derived from mitochondria-targeting luminescent iridium(III) poly(ethylene glycol) complexes modified with a nitrobenzyl linkage

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Abstract

Two novel photoactivatable mitochondria-targeting luminescent iridium(III) poly(ethylene glycol) (PEG) complexes incorporated with a nitrobenzyl group were designed. They showed minimal cytotoxic activity in the dark, but became significantly cytotoxic upon irradiation due to the release of the PEG pendants.

Graphical abstract: Photoactivatable cytotoxic agents derived from mitochondria-targeting luminescent iridium(iii) poly(ethylene glycol) complexes modified with a nitrobenzyl linkage

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Publication details

The article was received on 29 Jan 2016, accepted on 23 Feb 2016 and first published on 24 Feb 2016


Article type: Communication
DOI: 10.1039/C6CC00918B
Citation: Chem. Commun., 2016,52, 4557-4560
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    Photoactivatable cytotoxic agents derived from mitochondria-targeting luminescent iridium(III) poly(ethylene glycol) complexes modified with a nitrobenzyl linkage

    K. K. Tso, K. Leung, H. Liu and K. K. Lo, Chem. Commun., 2016, 52, 4557
    DOI: 10.1039/C6CC00918B

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