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Issue 34, 2016
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How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

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Abstract

Cocrystals of a weakly basic drug (nevirapine) with acidic coformers are shown to alter the solubility dependence on pH, and to exhibit a pHmax above which a less soluble cocrystal becomes more soluble than the drug. The cocrystal solubility advantage can be dialed up or down by solution pH.

Graphical abstract: How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

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Publication details

The article was received on 28 Jan 2016, accepted on 29 Mar 2016 and first published on 29 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC00898D
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 5832-5835
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    How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

    G. Kuminek, N. Rodríguez-Hornedo, S. Siedler, H. V. A. Rocha, S. L. Cuffini and S. G. Cardoso, Chem. Commun., 2016, 52, 5832
    DOI: 10.1039/C6CC00898D

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