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Issue 16, 2016
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Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

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Abstract

We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol–gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-α-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus.

Graphical abstract: Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

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Publication details

The article was received on 19 Jan 2016, accepted on 25 Jan 2016 and first published on 25 Jan 2016


Article type: Communication
DOI: 10.1039/C6CC00501B
Citation: Chem. Commun., 2016,52, 3352-3355
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    Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

    Z. Zhang, B. Schepens, L. Nuhn, X. Saelens, M. Schotsaert, N. Callewaert, R. De Rycke, Q. Zhang, S. Moins, S. Benali, L. Mespouille, R. Hoogenboom and B. G. De Geest, Chem. Commun., 2016, 52, 3352
    DOI: 10.1039/C6CC00501B

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