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Issue 15, 2016
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Cascade Pd(II)-catalyzed Wacker lactonization–Heck reaction: rapid assembly of spiranoid lactones

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Abstract

An unprecedented Pd-catalyzed cascade Wacker–Heck lactonization-cyclization sequence is reported. The process provides a facile approach to bi- and tricyclic spiranoid lactones in good yields. The reaction shows general substrate scope and a broad functional group tolerability. In addition, a rare 4-exo trig Heck-type cyclization is demonstrated.

Graphical abstract: Cascade Pd(ii)-catalyzed Wacker lactonization–Heck reaction: rapid assembly of spiranoid lactones

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Publication details

The article was received on 02 Dec 2015, accepted on 07 Jan 2016 and first published on 08 Jan 2016


Article type: Communication
DOI: 10.1039/C5CC09923D
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 3095-3098
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    Cascade Pd(II)-catalyzed Wacker lactonization–Heck reaction: rapid assembly of spiranoid lactones

    G. Albarghouti, R. Kotikalapudi, D. Lankri, V. Valerio and D. Tsvelikhovsky, Chem. Commun., 2016, 52, 3095
    DOI: 10.1039/C5CC09923D

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