Issue 14, 2016

Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging

Abstract

A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized 13C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized 13C pH imaging in a phantom and in vivo in a murine model of prostate cancer.

Graphical abstract: Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging

Supplementary files

Article information

Article type
Communication
Submitted
24 Nov 2015
Accepted
12 Jan 2016
First published
12 Jan 2016

Chem. Commun., 2016,52, 3030-3033

Author version available

Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging

D. E. Korenchan, R. R. Flavell, C. Baligand, R. Sriram, K. Neumann, S. Sukumar, H. VanBrocklin, D. B. Vigneron, D. M. Wilson and J. Kurhanewicz, Chem. Commun., 2016, 52, 3030 DOI: 10.1039/C5CC09724J

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