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Issue 10, 2016
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Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

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Abstract

Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.

Graphical abstract: Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

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Publication details

The article was received on 05 Nov 2015, accepted on 14 Dec 2015 and first published on 15 Dec 2015


Article type: Communication
DOI: 10.1039/C5CC09164K
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 2126-2128
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    Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

    K. B. Daniel, C. E. Callmann, N. C. Gianneschi and S. M. Cohen, Chem. Commun., 2016, 52, 2126
    DOI: 10.1039/C5CC09164K

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