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Issue 44, 2016
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Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

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Abstract

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.

Graphical abstract: Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

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Publication details

The article was received on 06 Oct 2015, accepted on 25 Apr 2016 and first published on 26 Apr 2016


Article type: Communication
DOI: 10.1039/C5CC08325G
Citation: Chem. Commun., 2016,52, 7114-7117
  • Open access: Creative Commons BY license
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    Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

    S. Nigam, B. P. Burke, L. H. Davies, J. Domarkas, J. F. Wallis, P. G. Waddell, J. S. Waby, D. M. Benoit, A. Seymour, C. Cawthorne, L. J. Higham and S. J. Archibald, Chem. Commun., 2016, 52, 7114
    DOI: 10.1039/C5CC08325G

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