Issue 6, 2016
From the journal:

Chemical Communications

High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides†

Ilaria Gamba,a   Iria Salvadó,a   Rosa F. Brissos,b   Patrick Gamez,bc   José Brea,d   María Isabel Loza,d   M. Eugenio Vázquez*e  and  Miguel Vázquez López*a  

* Corresponding authors

a Departamento de Química Inorgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
E-mail: miguel.vazquez.lopez@usc.es

b Departament de Química Inorgánica, QBI, Universitat de Barcelona, 08028 Barcelona, Spain

c Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain

d Grupo de Investigación BioFarma/Plataforma de Screening USEF, Centro de Investigación CIMUS, Universidade de Santiago de Compostela, Spain

e Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
E-mail: eugenio.vazquez@usc.es

Abstract

We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines.

Graphical abstract: High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides

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Article information

DOI
https://doi.org/10.1039/C5CC07619F
Article type
Communication
Submitted
11 Sep 2015
Accepted
18 Nov 2015
First published
23 Nov 2015

Chem. Commun., 2016,52, 1234-1237

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High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides

I. Gamba, I. Salvadó, R. F. Brissos, P. Gamez, J. Brea, M. I. Loza, M. E. Vázquez and M. V. López, Chem. Commun., 2016, 52, 1234 DOI: 10.1039/C5CC07619F

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