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Issue 6, 2016
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High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides

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Abstract

We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines.

Graphical abstract: High-affinity sequence-selective DNA binding by iridium(iii) polypyridyl organometallopeptides

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Publication details

The article was received on 11 Sep 2015, accepted on 18 Nov 2015 and first published on 23 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC07619F
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2016,52, 1234-1237
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    High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides

    I. Gamba, I. Salvadó, R. F. Brissos, P. Gamez, J. Brea, M. I. Loza, M. E. Vázquez and M. V. López, Chem. Commun., 2016, 52, 1234
    DOI: 10.1039/C5CC07619F

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