Issue 6, 2016

Switchable asymmetric bio-epoxidation of α,β-unsaturated ketones

Abstract

Efficient asymmetric bio-epoxidation of electron-deficient α,β-unsaturated ketones was realized via a tandem reduction-epoxidation-dehydrogenation cascade, which proceeds in a switchable manner to afford either chiral epoxy ketones or allylic epoxy alcohols with up to >99% yield and >99%ee.

Graphical abstract: Switchable asymmetric bio-epoxidation of α,β-unsaturated ketones

Supplementary files

Article information

Article type
Communication
Submitted
09 Sep 2015
Accepted
16 Nov 2015
First published
16 Nov 2015

Chem. Commun., 2016,52, 1158-1161

Author version available

Switchable asymmetric bio-epoxidation of α,β-unsaturated ketones

Y. Liu and Z. Wu, Chem. Commun., 2016, 52, 1158 DOI: 10.1039/C5CC07548C

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