Issue 2, 2016
From the journal:

Biomaterials Science

Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro†

Sujit Kootala,a   Yu Zhang,a   Sara Ghalib,a   Vladimir Tolmachev, ORCID logo b   Jöns Hilborn ORCID logo a  and  Dmitri A. Ossipov ORCID logo *a  

* Corresponding authors

a Science for Life Laboratory, Department of Chemistry-Ångström Laboratory, Uppsala University, Uppsala, Sweden
E-mail: dmitri.ossipov@kemi.uu.se

b Unit of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, S-75121 Uppsala, Sweden

Abstract

An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures.

Graphical abstract: Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro

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Article information

DOI
https://doi.org/10.1039/C5BM00355E
Article type
Communication
Submitted
31 Aug 2015
Accepted
10 Nov 2015
First published
27 Nov 2015

Biomater. Sci., 2016,4, 250-254

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Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro

S. Kootala, Y. Zhang, S. Ghalib, V. Tolmachev, J. Hilborn and D. A. Ossipov, Biomater. Sci., 2016, 4, 250 DOI: 10.1039/C5BM00355E

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