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Issue 41, 2016
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Characterisation of matrix-based polyatomic interference formation in laser ablation-inductively coupled plasma-mass spectrometry using dried micro-droplet ablation and its relevance for bioimaging

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Abstract

Dried micro-droplets were used to characterise the formation of polyatomic interferences in a commercial laser ablation-inductively coupled plasma-mass spectrometer (LA-ICP-MS). Droplets containing 4 ng each of Al, As, Ca, Cd, Co, Cu, Fe, Mg, Mn, P, Se and Zn in the presence of potentially interfering isotopes were deposited on silicate microscope slides. Comparisons of the total signal recorded for each dried droplet showed no detectable influence of polyatomic matrix-based interferences. Visualisation of acquired signal was achieved by the generation of two-dimensional maps. The natural abundance pattern of elements with two measurable isotopes was confirmed for each droplet. The lack of interferences was due to the absence of major gas molecules (e.g. N2, O2, CO2) from the laser cell and minimal total matrix load on the plasma when compared to standard solution nebulisation (approx. ng s−1versus 10–20 μL s−1) ICP-MS conditions.

Graphical abstract: Characterisation of matrix-based polyatomic interference formation in laser ablation-inductively coupled plasma-mass spectrometry using dried micro-droplet ablation and its relevance for bioimaging

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Publication details

The article was received on 10 Sep 2016, accepted on 01 Oct 2016 and first published on 03 Oct 2016


Article type: Technical Note
DOI: 10.1039/C6AY02545E
Citation: Anal. Methods, 2016,8, 7552-7556
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    Characterisation of matrix-based polyatomic interference formation in laser ablation-inductively coupled plasma-mass spectrometry using dried micro-droplet ablation and its relevance for bioimaging

    D. J. Hare, F. Fryer, B. Paul, D. P. Bishop and P. A. Doble, Anal. Methods, 2016, 8, 7552
    DOI: 10.1039/C6AY02545E

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