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Issue 44, 2016
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A high-throughput BIA-MPA method for the simultaneous determination of amiloride and furosemide

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Abstract

In this work, a simple and fast batch injection analysis system with multiple pulse amperometric detection (BIA-MPA) was developed for the simultaneous determination of amiloride (AMD) and furosemide (FMD). A sample plug (150 μL) was directly injected into the unmodified boron-doped diamond (BDD) electrode immersed in 0.1 mol L−1 borate buffer (pH = 10). Simple and fast sample pre-treatment steps were required (dissolution and dilution). The analytical characteristics of the proposed method include good stability (RSD < 1.1%; n = 20), low detection limits (0.13 and 0.94 mg L−1 for AMD and FMD, respectively), high throughput (72 injections per h) and minimal waste production (∼150 μL by analysis). The results obtained with the BIA-MPA method were compared to those obtained by HPLC; similar results were obtained (at a 95% confidence level).

Graphical abstract: A high-throughput BIA-MPA method for the simultaneous determination of amiloride and furosemide

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Publication details

The article was received on 06 Sep 2016, accepted on 13 Oct 2016 and first published on 14 Oct 2016


Article type: Paper
DOI: 10.1039/C6AY02506D
Citation: Anal. Methods, 2016,8, 7959-7965
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    A high-throughput BIA-MPA method for the simultaneous determination of amiloride and furosemide

    P. F. Pereira, W. P. da Silva, M. C. Marra, R. A. A. Muñoz and E. M. Richter, Anal. Methods, 2016, 8, 7959
    DOI: 10.1039/C6AY02506D

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