Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 43, 2016
Previous Article Next Article

Hollow fiber-based solid–liquid phase microextraction combined with theta capillary electrospray ionization mass spectrometry for sensitive and accurate analysis of methamphetamine

Author affiliations

Abstract

This paper presents a new method for quantitative analysis of methamphetamine (MAP) in urine samples based on hollow fiber-based solid–liquid phase microextraction (HF-SLPME) in combination with theta capillary-electrospray ionization mass spectrometry (TC-ESI-MS) detection. In the lumen of the hollow fiber, metal organic frameworks/graphene oxide (MOF/GO) hybrid material dispersed in 1-octanol was used as the acceptor phase for the enrichment of MAP. For TC-ESI-MS detection, the ESI emitter has a theta capillary with two separate channels and one common emitter tip. The MAP solution and the reference dopamine solution were separately loaded into the two channels. The ratio of signal intensities between MAP and dopamine was used for the evaluation of the extraction efficiency. Several experimental parameters influencing the extraction efficiency were investigated and optimized. Under the optimized conditions, the limit of detection was 0.5 ng mL−1, and the linearity range was 2.0–200.0 ng mL−1, with the correlation coefficient (R2) at 0.9997, indicating that the method based on HF-SLPME combined with TC-ESI-MS is sensitive and accurate for the determination of MAP in urine samples and would have utility in other types of trace chemical analyses.

Graphical abstract: Hollow fiber-based solid–liquid phase microextraction combined with theta capillary electrospray ionization mass spectrometry for sensitive and accurate analysis of methamphetamine

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 11 Aug 2016, accepted on 03 Oct 2016 and first published on 07 Oct 2016


Article type: Paper
DOI: 10.1039/C6AY02254E
Citation: Anal. Methods, 2016,8, 7800-7807
  •   Request permissions

    Hollow fiber-based solid–liquid phase microextraction combined with theta capillary electrospray ionization mass spectrometry for sensitive and accurate analysis of methamphetamine

    Z. Li, S. Zhang, Y. Cai, Q. Wu and H. Chen, Anal. Methods, 2016, 8, 7800
    DOI: 10.1039/C6AY02254E

Search articles by author