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Issue 43, 2016
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Electrochemical determination of mesalazine by using graphene oxide coated with a molecularly imprinted sol–gel

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Abstract

Graphene oxide coated with a molecularly imprinted sol–gel was prepared by one-pot synthesis from phenyltriethoxysilane and tetramethoxysilane. The composite modified electrode was used for electrochemical determination of mesalazine (ASA) by differential pulse voltammetry (DPV) in Britton–Robinson buffer solution (pH = 2.0). The peak current was linear with the concentration in the range from 2 to 20 μmol L−1 (r2 = 0.9955) and 20 to 150 μmol L−1 (r2 = 0.9987) with a detection limit of 0.97 μmol L−1 (S/N = 3). Interferents with similar structures such as salicylic acid, 4-aminophenol, 2-aminobenzoic acid and 4-acetamidophenol were examined. The utilizability and reliability of this method were confirmed by the determination of mesalazine in a drug tablet.

Graphical abstract: Electrochemical determination of mesalazine by using graphene oxide coated with a molecularly imprinted sol–gel

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Publication details

The article was received on 10 Aug 2016, accepted on 11 Oct 2016 and first published on 11 Oct 2016


Article type: Paper
DOI: 10.1039/C6AY02243J
Citation: Anal. Methods, 2016,8, 7780-7788
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    Electrochemical determination of mesalazine by using graphene oxide coated with a molecularly imprinted sol–gel

    S. Kim, N. Wang, Y. Li and X. He, Anal. Methods, 2016, 8, 7780
    DOI: 10.1039/C6AY02243J

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