Issue 4, 2016

Synthesis and modification of monodisperse silica microspheres for UPLC separation of C60 and C70

Abstract

Monodisperse silica microspheres with average diameters from 1 μm to 2 μm were synthesized by a modified Stöber method, in which an ethanolic solution of tetraethyl orthosilicate (TEOS) was continuously supplied to the reaction mixture containing KCl electrolyte, water, ethanol and ammonia. The effects of reactant amounts, supply rate, and reaction temperature on the microsphere morphology were investigated. After surface modification with octadecyl trichlorosilane, the obtained monodisperse C18-silica microspheres with an average diameter of 1.5 μm were applied to ultra performance liquid chromatography (UPLC) separation of fullerenes. Because of having a smaller size, the 1.5 μm monodisperse C18-silica UPLC stationary phase shows ultra high efficiency compared with the commercial C18-silica HPLC stationary phase with average diameters from 5 to 50 μm.

Graphical abstract: Synthesis and modification of monodisperse silica microspheres for UPLC separation of C60 and C70

Supplementary files

Article information

Article type
Paper
Submitted
06 Oct 2015
Accepted
14 Dec 2015
First published
17 Dec 2015

Anal. Methods, 2016,8, 919-924

Author version available

Synthesis and modification of monodisperse silica microspheres for UPLC separation of C60 and C70

B. Yu, H. Cong, L. Xue, C. Tian, X. Xu, Q. Peng and S. Yang, Anal. Methods, 2016, 8, 919 DOI: 10.1039/C5AY02655E

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