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Issue 24, 2016
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Label-free DNA-based biosensors using structure-selective light-up dyes

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Label-free biosensors (LFBs) have demonstrated a great potential in cost-effective applications, and most of the DNA-based LFBs are based on the principle of binding-induced structural transformation. This review is a collection of the latest reported studies, which have employed structure-selective nucleic acid dyes for the development of DNA-based LFBs. The collections in this review have been structured based on the selective binding of dyes towards specific DNA conformations, including single-stranded DNA, double-stranded DNA, triplex DNA, i-motifs and G-quadruplexes. The newest studies of employing versatile nucleases, fascinating nanomaterials, logic gates and cascades, DNA junctions and nanostructures have also been collected as examples. It is predicted that the imperative requirement for ultrahigh sensitivity, intelligent analysis, reliable detection, portable and fast assay would force the LFB development in a stimulative and continuous way.

Graphical abstract: Label-free DNA-based biosensors using structure-selective light-up dyes

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The article was received on 01 Sep 2016, accepted on 11 Oct 2016 and first published on 12 Oct 2016

Article type: Minireview
DOI: 10.1039/C6AN01958G
Citation: Analyst, 2016,141, 6481-6489
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    Label-free DNA-based biosensors using structure-selective light-up dyes

    Y. Guo, L. Xu, S. Hong, Q. Sun, W. Yao and R. Pei, Analyst, 2016, 141, 6481
    DOI: 10.1039/C6AN01958G

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