Issue 16, 2016
From the journal:

Analyst

DNA-fueled molecular machine for label-free and non-enzymatic ultrasensitive detection of telomerase activity†

Panpan Sun,ab   Xiang Ran,ab   Chaoqun Liu,ab   Chaoying Liu,*c   Fang Pu,a   Jinsong Ren*a  and  Xiaogang Qua  

* Corresponding authors

a Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China
E-mail: jren@ciac.ac.cn

b University of Chinese Academy of Sciences, Beijing 100039, China

c Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, China

Abstract

Herein, a non-enzymatic and label-free strategy based on DNA-fueled molecular machine was developed for ultrasensitive detection of telomerase activity in cancer cell extracts even at the single-cell level.

Graphical abstract: DNA-fueled molecular machine for label-free and non-enzymatic ultrasensitive detection of telomerase activity

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Article information

DOI
https://doi.org/10.1039/C6AN00997B
Article type
Communication
Submitted
29 Apr 2016
Accepted
05 Jul 2016
First published
05 Jul 2016

Analyst, 2016,141, 4855-4858

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DNA-fueled molecular machine for label-free and non-enzymatic ultrasensitive detection of telomerase activity

P. Sun, X. Ran, C. Liu, C. Liu, F. Pu, J. Ren and X. Qu, Analyst, 2016, 141, 4855 DOI: 10.1039/C6AN00997B

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