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Issue 8, 2016
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Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry

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Abstract

The combination of stable isotope labelling with direct infusion ion mobility mass spectrometry (IM-MS) enabled qualitative and quantitative monitoring of biocatalytic reactions with reduced analysis times, enhanced sensitivity and μL-level assay volumes. The new approach was demonstrated by applying to both lipase and monooxygenase enzymes, including multi-substrate screening.

Graphical abstract: Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry

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Publication details

The article was received on 15 Mar 2016, accepted on 15 Mar 2016 and first published on 15 Mar 2016


Article type: Communication
DOI: 10.1039/C6AN00617E
Author version available: Download Author version (PDF)
Citation: Analyst, 2016,141, 2351-2355
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    Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry

    C. Yan, J. W. Schmidberger, F. Parmeggiani, S. A. Hussain, N. J. Turner, S. L. Flitsch and P. Barran, Analyst, 2016, 141, 2351
    DOI: 10.1039/C6AN00617E

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