Issue 4, 2016
From the journal:

Analyst

Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide†

Jianwei Chen,‡a   Mingkun Zhao,‡b   Xiqian Jiang,a   Antons Sizovs,a   Meng C. Wang,c   Christopher R. Provost,d   Jia Huange  and  Jin Wang*af  

* Corresponding authors

a Department of Pharmacology, Houston, TX 77030, USA
E-mail: wangj@bcm.edu

b Integrative Molecular and Biomedical Sciences Graduate Program, Houston, TX 77030, USA

c Department of Molecular and Human Genetics and Huffington Centre on Aging, Houston, TX 77030, USA

d New England Biolabs, Ipswich, MA 01938, USA

e Sciclotron LLC, Sugar Land, TX 77479, USA

f Centre for Drug Discovery, Dan L. Duncan Cancer Centre, and Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA

Abstract

Imaging hydrogen sulfide (H2S) at the subcellular resolution will greatly improve the understanding of functions of this signaling molecule. Taking advantage of the protein labeling technologies, we report a general strategy for the development of organelle specific H2S probes, which enables sub-cellular H2S imaging essentially in any organelles of interest.

Graphical abstract: Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide

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Article information

DOI
https://doi.org/10.1039/C5AN02497H
Article type
Communication
Submitted
04 Dec 2015
Accepted
14 Jan 2016
First published
14 Jan 2016

Analyst, 2016,141, 1209-1213

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Genetically anchored fluorescent probes for subcellular specific imaging of hydrogen sulfide

J. Chen, M. Zhao, X. Jiang, A. Sizovs, M. C. Wang, C. R. Provost, J. Huang and J. Wang, Analyst, 2016, 141, 1209 DOI: 10.1039/C5AN02497H

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