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Issue 47, 2015
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Facile synthesis of hyaluronic acid-modified Fe3O4/Au composite nanoparticles for targeted dual mode MR/CT imaging of tumors

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Abstract

A facile co-precipitation approach for synthesizing hyaluronic acid (HA)-modified Fe3O4/Au composite nanoparticles (CNPs) for targeted dual mode tumor magnetic resonance (MR) and computed tomography (CT) imaging is reported. In this work, polyethyleneimine (PEI) was employed as a stabilizer to form gold NPs (PEI–Au NPs). In the presence of the PEI–Au NPs, controlled co-precipitation of Fe(II) and Fe(III) salts was performed, leading to the formation of the Fe3O4/Au–PEI CNPs, which were further modified with hyaluronic acid (HA). We show that the formed Fe3O4/Au–PEI–HA CNPs are colloidally stable, hemocompatible and cytocompatible in a given concentration range, and have a high affinity to target CD44 receptor-overexpressing cancer cells. Due to the presence of Fe3O4 and Au components, the formed Fe3O4/Au–PEI–HA CNPs display a high r2 relaxivity (264.16 mM−1 s−1) and good X-ray attenuation property, rendering them with an ability to be used as a nanoprobe for targeted dual mode MR/CT imaging of CD44 receptor-overexpressing cancer cells in vitro and a xenografted tumor model in vivo. The Fe3O4/Au–PEI–HA CNPs developed via this facile approach may hold great promise to be used as a unique platform for precision imaging of CD44 receptor-overexpressing tumors.

Graphical abstract: Facile synthesis of hyaluronic acid-modified Fe3O4/Au composite nanoparticles for targeted dual mode MR/CT imaging of tumors

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Publication details

The article was received on 30 Sep 2015, accepted on 23 Oct 2015 and first published on 23 Oct 2015


Article type: Paper
DOI: 10.1039/C5TB02040A
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Citation: J. Mater. Chem. B, 2015,3, 9098-9108
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    Facile synthesis of hyaluronic acid-modified Fe3O4/Au composite nanoparticles for targeted dual mode MR/CT imaging of tumors

    Y. Hu, J. Yang, P. Wei, J. Li, L. Ding, G. Zhang, X. Shi and M. Shen, J. Mater. Chem. B, 2015, 3, 9098
    DOI: 10.1039/C5TB02040A

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