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Issue 39, 2015
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Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

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Abstract

The recently developed poly(glycerol sebacate) (PGS) has been gaining attraction as a biomaterial for tissue engineering applications. Reported in 2002, a simple polycondensation method was developed to synthesize PGS for soft tissue engineering applications. It has since become a highly sought after biomaterial due to its soft, robust and flexible characteristics and it is relatively low cost compared to other biodegradable elastomers currently available in the market. We summarise in this review, the various synthetic approaches of PGS and highlight selected applications in nerve guidance, soft tissue regeneration, vascular and myocardial tissue regeneration, blood vessel reconstruction, drug delivery, and the replacement of photoreceptor cells. A critical assessment of the material is provided as a scope for future improvement. The future outlook of this material is also provided at the end of this review.

Graphical abstract: Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

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Publication details

The article was received on 31 May 2015, accepted on 11 Aug 2015 and first published on 12 Aug 2015


Article type: Review Article
DOI: 10.1039/C5TB01048A
Citation: J. Mater. Chem. B, 2015,3, 7641-7652
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    Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

    X. J. Loh, A. Abdul Karim and C. Owh, J. Mater. Chem. B, 2015, 3, 7641
    DOI: 10.1039/C5TB01048A

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