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Issue 20, 2015
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Au nanoparticle-coated, PLGA-based hybrid capsules for combined ultrasound imaging and HIFU therapy

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Abstract

Herein, we present a simple method to prepare Au nanoparticle-coated, polydopamine-modified poly(lactic-co-glycolic acid) (AuNPs@PDA/PLGA) hybrid capsules for combined ultrasound imaging and high-intensity focused ultrasound (HIFU) therapy. In this approach, PLGA nanocapsules are prepared firstly via a facile and efficient water/oil/water (W/O/W) emulsion strategy, and are then modified with PDA through the self-polymerization of dopamine in a weakly alkaline aqueous environment. Subsequently, chloroauric acid (HAuCl4) solution is added, and AuCl4 ions are absorbed on the surfaces of the PDA/PLGA nanocapsules by the active catechol and amine groups of PDA coatings. Finally, these absorbed AuCl4 ions are reduced in situ to AuNPs to form AuNPs@PDA/PLGA hybrid capsules. The in vitro ultrasound imaging experiments show that AuNPs@PDA/PLGA hybrid capsules are suitable for ultrasound contrast imaging. Moreover, the potential of the nanocapsules to enhance HIFU therapy is also demonstrated. These results show that ultrasound-guided HIFU therapy ex vivo with AuNPs@PDA/PLGA hybrid capsules is highly efficient on degassed bovine livers due to the high thermal energy accumulation of AuNPs. Thus, the successful integration of the AuNPs and PLGA nanocapsules provides an alternative strategy for highly efficient ultrasound-guided HIFU therapy.

Graphical abstract: Au nanoparticle-coated, PLGA-based hybrid capsules for combined ultrasound imaging and HIFU therapy

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Publication details

The article was received on 28 Jan 2015, accepted on 15 Apr 2015 and first published on 16 Apr 2015


Article type: Paper
DOI: 10.1039/C5TB00200A
Citation: J. Mater. Chem. B, 2015,3, 4213-4220
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    Au nanoparticle-coated, PLGA-based hybrid capsules for combined ultrasound imaging and HIFU therapy

    J. Xi, X. Qian, K. Qian, W. Zhang, W. He, Y. Chen, J. Han, Y. Zhang, X. Yang and L. Fan, J. Mater. Chem. B, 2015, 3, 4213
    DOI: 10.1039/C5TB00200A

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