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Issue 9, 2015
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Fine-tuning thermoresponsive functional poly(ε-caprolactone)s to enhance micelle stability and drug loading

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Abstract

Block copolymers synthesized by the ring-opening polymerization of γ-2-[2-(2-methoxyethoxy)ethoxy]ethoxy-ε-caprolactone (ME3CL), γ-2-methoxyethoxy-ε-caprolactone (ME1CL), and ε-caprolactone (CL) are reported. Previously, diblock copolymers of PME3CL-b-PME1CL displayed excellent thermoresponsive tunability (31–43 °C) and self-assembled into micelles with moderate thermodynamic stability. In this report, two strategies are employed to enhance thermodynamic stability of PME3CL/PME1CL-type block copolymer micelles while maintaining their attractive thermoresponsive qualities: modification of the end group position and alteration of hydrophobic block composition by using both ME1CL and CL. These new thermoresponsive amphiphilic block copolymers showed lower critical micelle concentration (CMC) values by one order of magnitude and formed thermodynamically stable micelles. Furthermore they demonstrated good biocompatibility and up to 4.97 wt% doxorubicin loading, more than double the amount loaded into the PME3CL-type polymeric micelles previously reported.

Graphical abstract: Fine-tuning thermoresponsive functional poly(ε-caprolactone)s to enhance micelle stability and drug loading

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Publication details

The article was received on 08 Dec 2014, accepted on 16 Jan 2015 and first published on 16 Jan 2015


Article type: Paper
DOI: 10.1039/C4TB02016B
Author version available: Download Author version (PDF)
Citation: J. Mater. Chem. B, 2015,3, 1779-1787
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    Fine-tuning thermoresponsive functional poly(ε-caprolactone)s to enhance micelle stability and drug loading

    E. A. Rainbolt, J. B. Miller, K. E. Washington, S. A. Senevirathne, M. C. Biewer, D. J. Siegwart and M. C. Stefan, J. Mater. Chem. B, 2015, 3, 1779
    DOI: 10.1039/C4TB02016B

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