Jump to main content
Jump to site search

Issue 3, 2015
Previous Article Next Article

Plasmonic photothermal destruction of uropathogenic E. coli with reduced graphene oxide and core/shell nanocomposites of gold nanorods/reduced graphene oxide

Author affiliations

Abstract

The development of non-antibiotic based treatments against bacterial infections by Gram-negative uropathogenic E. coli is a complex task. New strategies to treat such infections are thus urgently needed. This report illustrates the development of pegylated reduced graphene oxide nanoparticles (rGO-PEG) and gold nanorods (Au NRs) coated with rGO-PEG (rGO-PEG-Au NRs) for the selective killing of uropathogenic E. coli UTI89. We took advantage of the excellent light absorption properties of rGO-PEG and Au NR particles in the near-infrared (NIR) region to photothermally kill Gram-negative pathogens up to 99% in 10 min by illumination of solutions containing the bacteria. The rGO-PEG-Au NRs demonstrated better photothermal efficiency towards E. coli than rGO-PEG. Targeted killing of E. coli UTI89 could be achieved with rGO-PEG-Au NRs functionalized with multimeric heptyl α-D-mannoside probes. This currently offers a unique biocompatible method for the ablation of pathogens with the opening of probably a new possibility for clinical treatments of patients with urinary infections.

Graphical abstract: Plasmonic photothermal destruction of uropathogenic E. coli with reduced graphene oxide and core/shell nanocomposites of gold nanorods/reduced graphene oxide

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 23 Oct 2014, accepted on 19 Nov 2014 and first published on 19 Nov 2014


Article type: Paper
DOI: 10.1039/C4TB01760A
Citation: J. Mater. Chem. B, 2015,3, 375-386
  •   Request permissions

    Plasmonic photothermal destruction of uropathogenic E. coli with reduced graphene oxide and core/shell nanocomposites of gold nanorods/reduced graphene oxide

    K. Turcheniuk, C. Hage, J. Spadavecchia, A. Y. Serrano, I. Larroulet, A. Pesquera, A. Zurutuza, M. G. Pisfil, L. Héliot, J. Boukaert, R. Boukherroub and S. Szunerits, J. Mater. Chem. B, 2015, 3, 375
    DOI: 10.1039/C4TB01760A

Search articles by author