Jump to main content
Jump to site search

Issue 2, 2015
Previous Article Next Article

Siderophore-inspired nanoparticle-based biosensor for the selective detection of Fe3+

Author affiliations

Abstract

Inspired by nature's exploitation of the 1,2-dihydroxybenzene unit (or catechol) in mammalian and bacterial siderophores, we report the first example of a nanoparticle sensing system that utilises the strong catechol–Fe3+ binding motif to trigger nanoparticle aggregation, promoting a powerful optical response. Gold nanoparticles are functionalised with RAFT polymerisation-prepared water-soluble poly(N-hydroxyethyl acrylamide) containing a catechol moiety at the α-chain-end. A strong red-to-purple colorimetric response occurs in the presence of Fe3+ at serum concentrations (8–25 μM) in saline solution. Sodium chloride is critical in generating a strong optical output, as is the length of polymer used to coat the AuNPs. This behaviour is also demonstrated to be selective for Fe3+ over a host of other biologically relevant ions.

Graphical abstract: Siderophore-inspired nanoparticle-based biosensor for the selective detection of Fe3+

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Sep 2014, accepted on 05 Nov 2014 and first published on 07 Nov 2014


Article type: Paper
DOI: 10.1039/C4TB01501K
Citation: J. Mater. Chem. B, 2015,3, 270-275
  •   Request permissions

    Siderophore-inspired nanoparticle-based biosensor for the selective detection of Fe3+

    D. J. Phillips, G. Davies and M. I. Gibson, J. Mater. Chem. B, 2015, 3, 270
    DOI: 10.1039/C4TB01501K

Search articles by author

Spotlight

Advertisements