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Issue 46, 2015
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Nucleation of symmetric domains in the coupled leaflets of a bilayer

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Abstract

We study the kinetics governing the attainment of inter-leaflet domain symmetry in a phase-separating amphiphilic bilayer. “Indirect” inter-leaflet coupling via hydrophobic mismatch can induce an instability towards a metastable pattern of locally asymmetric domains upon quenching from high temperature. This necessitates a nucleation step to form the conventional symmetric domains, which are favoured by a “direct” inter-leaflet coupling. We model the energetics for a symmetric domain to nucleate from the metastable state, and find that an interplay between hydrophobic mismatch and thickness stretching/compression causes the effective hydrophobic mismatch, and thus line tension, to depend on domain size. This leads to strong departure from classical nucleation theory. We speculate on implications for cell membrane rafts or clusters, whose size may be of similar magnitude to estimated critical radii for domain symmetry.

Graphical abstract: Nucleation of symmetric domains in the coupled leaflets of a bilayer

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Publication details

The article was received on 29 May 2015, accepted on 08 Sep 2015 and first published on 28 Sep 2015


Article type: Paper
DOI: 10.1039/C5SM01328C
Citation: Soft Matter, 2015,11, 8948-8959
  • Open access: Creative Commons BY license
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    Nucleation of symmetric domains in the coupled leaflets of a bilayer

    J. J. Williamson and P. D. Olmsted, Soft Matter, 2015, 11, 8948
    DOI: 10.1039/C5SM01328C

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