Self-assembling amphiphilic poly(propargyl methacrylate) grafted DNA copolymers into multi-strand helices

Abstract

DNA was covalently grafted onto poly(propargyl methacrylate) (PPMA) via “click” chemistry to synthesize the amphiphilic polymer brush. The PPMA-g-DNA brush could assemble into a primary structure of a nanofiber, which can be compactly spun into a multiple-strand helix in micron-length. The brush could also self-assemble with DNA labelled gold nanoparticles.