Jump to main content
Jump to site search

Issue 5, 2015
Previous Article Next Article

Structure elucidation of nigricanoside A through enantioselective total synthesis

Author affiliations

Abstract

Nigricanoside A was isolated from green alga, and its dimethyl ester was found to display potent cytotoxicity. Its scarcity prevented a full structure elucidation, leaving total synthesis as the only means to determine its relative and absolute stereochemistry and to explore its biological activity. Here we assign the stereochemistry of the natural product through enantioselective total synthesis and provide initial studies of its cytotoxicity.

Graphical abstract: Structure elucidation of nigricanoside A through enantioselective total synthesis

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Jan 2015, accepted on 12 Mar 2015 and first published on 12 Mar 2015


Article type: Edge Article
DOI: 10.1039/C5SC00281H
Citation: Chem. Sci., 2015,6, 2932-2937
  • Open access: Creative Commons BY license
  •   Request permissions

    Structure elucidation of nigricanoside A through enantioselective total synthesis

    J. Chen, P. Koswatta, J. R. DeBergh, P. Fu, E. Pan, J. B. MacMillan and J. M. Ready, Chem. Sci., 2015, 6, 2932
    DOI: 10.1039/C5SC00281H

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements