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Issue 3, 2015
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Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

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Abstract

Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal–organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.

Graphical abstract: Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

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Publication details

The article was received on 04 Dec 2014, accepted on 24 Dec 2014 and first published on 24 Dec 2014


Article type: Edge Article
DOI: 10.1039/C4SC03749A
Citation: Chem. Sci., 2015,6, 1640-1644
  • Open access: Creative Commons BY-NC license
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    Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches

    L. Tan, H. Li, Y. Qiu, D. Chen, X. Wang, R. Pan, Y. Wang, S. X. Zhang, B. Wang and Y. Yang, Chem. Sci., 2015, 6, 1640
    DOI: 10.1039/C4SC03749A

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