Protein self-assembly induces promiscuous nucleophilic biocatalysis in Morita–Baylis–Hillman (MBH) reaction

Abstract

Self-assembled states of proteins render efficient promiscuous nucleophilic biocatalysis in MBH reaction in a green process. The His and Arg based catalophores in proteins operate in aqueous buffer at neutral pH and ambient temperature. Steady-state fluorimetric approaches reveal that lower order aggregates play a seminal role in the biocatalytic process.