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Issue 102, 2015
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Radiopaque poly(ε-caprolactone) as additive for X-ray imaging of temporary implantable medical devices

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Abstract

Implantable polymeric medical devices suffer from a lack of visibility under current clinical imaging techniques. To circumvent this problem, poly(ε-caprolactone-co-α-triiodobenzoate-ε-caprolactone)s (PCL-TIB) containing from 3.5% to 24% of triiodobenzoate-ε-caprolactone units were synthesized as new X-ray macromolecular contrast agents. Physico-chemical and thermal properties of PCL-TIBs were evaluated by 1H NMR, SEC, DSC and TGA. Their potential as radio-opacifying additive for medical devices was evaluated by preparing polymeric blends of PCL-TIB with various (co)polyesters. At first, in vitro X-ray visibility of PCL/PCL-TIB blends was evaluated. A more in depth characterization was then carried out based on PCL/PLA50-PEG-PLA50 blends. The impact of PCL-TIB content on the mechanical properties of blends was evaluated by tensile tests. Stability of X-ray visibility was evaluated by ex vivo implantation of non-degraded blends and of blends degraded for 6 weeks in vitro. Finally, cytocompatibility was assessed by evaluating the proliferation of L929 fibroblasts on the blends.

Graphical abstract: Radiopaque poly(ε-caprolactone) as additive for X-ray imaging of temporary implantable medical devices

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Publication details

The article was received on 21 Sep 2015, accepted on 29 Sep 2015 and first published on 30 Sep 2015


Article type: Paper
DOI: 10.1039/C5RA19488A
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 84125-84133
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    Radiopaque poly(ε-caprolactone) as additive for X-ray imaging of temporary implantable medical devices

    R. Samuel, E. Girard, G. Chagnon, S. Dejean, D. Favier, J. Coudane and B. Nottelet, RSC Adv., 2015, 5, 84125
    DOI: 10.1039/C5RA19488A

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