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Issue 95, 2015
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Functional wound dressing materials with highly tunable drug release properties

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Abstract

Wound dressings, capable of local controlled delivery of non-steroid anti-inflammatory pain-killing drugs (NSAIDs) to the wound bed, offer great potential to accelerate wound healing, hence increase the quality of patient life. With local NSAID delivery, unwanted side effects encountered in their systemic delivery, are drastically diminished. In this study, four functional fibrous wound dressing materials, namely viscose, alginate, sodium carboxymethyl cellulose (Na-CMC) and polyethylene terephthalate (PET) loaded with a NSAID, diclofenac sodium (DCF) are prepared, and their suitability to tune the release rate of DCF is evaluated. Through careful examination of material–drug combinations, in terms of their physicochemical properties (air permeability, wettability and water retention) and structural/morphological properties (infrared spectroscopy, wide angle X-ray scattering and scanning electron microscopy), possible wound care applications are proposed. In vitro release studies using an automated Franz diffusion cell system, combined with UV-Vis absorption spectroscopy for drug release profile determination, are performed as the final pre-formulation test. Results showed significant differences in the release profiles between different material–drug combinations, making the examined materials highly applicable for several wound care applications. The present study presents a novel cost effective approach for preparation of drug loaded wound dressing materials without a sacrifice in patient safety. Additionally, novel methods and material–drug combinations are introduced, paving the way for possible future wound treatment options.

Graphical abstract: Functional wound dressing materials with highly tunable drug release properties

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Publication details

The article was received on 21 Jun 2015, accepted on 09 Sep 2015 and first published on 09 Sep 2015


Article type: Paper
DOI: 10.1039/C5RA11972C
Citation: RSC Adv., 2015,5, 77873-77884
  • Open access: Creative Commons BY license
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    Functional wound dressing materials with highly tunable drug release properties

    T. Maver, S. Hribernik, T. Mohan, D. M. Smrke, U. Maver and K. Stana-Kleinschek, RSC Adv., 2015, 5, 77873
    DOI: 10.1039/C5RA11972C

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