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Issue 81, 2015
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Fabrication of amphiphilic fluorescent polylysine nanoparticles by atom transfer radical polymerization (ATRP) and their application in cell imaging

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Abstract

Due to the good biocompatibility, ε-polylysine (Ply) has been extensively investigated for various biomedical applications. In this study, a fluorescent monomer (named Flu-MA) was firstly synthesized through acylation reaction of fluorescein by methacryloyl chloride, and the initiator of ε-polylysine bromide (named Ply-Br) was prepared by the introduction of a bromine atom into Ply by the acylation reaction of Ply with α-bromoisobutyryl bromide. Subsequently, a novel amphiphilic fluorescent polymer (Flu-Ply) was successfully fabricated by ATRP via incorporation of Flu-MA monomer into Ply chains for the first time. The structure and properties of the obtained Flu-Ply fluorescent polymer were investigated in detail by 1H NMR, TEM, UV-vis, FL and FTIR, and the results confirmed the successful incorporation of Flu-MA into Ply by ATRP. As a result of Flu-MA and Ply respectively endowing the as-prepared Flu-Ply polymer with fluorescence and water dispersibility, it tended to self-assemble into fluorescent organic nanoparticles (FONs) with excellent biocompatibility. More importantly, the good fluorescence, uniform spherical morphology, excellent biocompatibility and water dispersibility of Flu-Ply FONs exhibited an attractive prospect for bioimaging applications.

Graphical abstract: Fabrication of amphiphilic fluorescent polylysine nanoparticles by atom transfer radical polymerization (ATRP) and their application in cell imaging

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Publication details

The article was received on 31 May 2015, accepted on 27 Jul 2015 and first published on 27 Jul 2015


Article type: Paper
DOI: 10.1039/C5RA10283A
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Citation: RSC Adv., 2015,5, 65884-65889
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    Fabrication of amphiphilic fluorescent polylysine nanoparticles by atom transfer radical polymerization (ATRP) and their application in cell imaging

    Z. Huang, X. Zhang, X. Zhang, S. Wang, B. Yang, K. Wang, J. Yuan, L. Tao and Y. Wei, RSC Adv., 2015, 5, 65884
    DOI: 10.1039/C5RA10283A

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