Issue 49, 2015

Synthesis of 2-trifluoromethyl indoles via visible-light induced intramolecular radical cyclization

Abstract

A visible-light induced intramolecular radical cyclization of N-[2-(alkynyl)phenyl]trifluoroacetimidoyl chlorides is described. The reaction allows the rapid construction of diverse 2-trifluoromethyl-3-acylindoles in a sequential C–C and C–O bond formation process under mild conditions.

Graphical abstract: Synthesis of 2-trifluoromethyl indoles via visible-light induced intramolecular radical cyclization

Supplementary files

Article information

Article type
Communication
Submitted
03 Apr 2015
Accepted
24 Apr 2015
First published
27 Apr 2015

RSC Adv., 2015,5, 39625-39629

Author version available

Synthesis of 2-trifluoromethyl indoles via visible-light induced intramolecular radical cyclization

X. Dong, Y. Hu, T. Xiao and L. Zhou, RSC Adv., 2015, 5, 39625 DOI: 10.1039/C5RA05967D

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