Issue 60, 2015

Dendritic magnetite decorated by pH-responsive PEGylated starch: a smart multifunctional nanocarrier for the triggered release of anti-cancer drugs

Abstract

In the present study, we designed a pH-responsive drug nanocarrier based on polyamidoamine-modified Fe3O4 nanoparticles coated by PEGylated starch-co-poly(acrylic acid). This carrier was used for the controlled release of doxorubicin as an anticancer drug model. The purpose of using the polyethylene glycol moiety is to generate a biostable nanocarrier in blood stream as it has been reported widely in the pharmaceutical literature. The use of a poly(acrylic acid) segment also provided pH-sensitivity to the polymer. Besides, the magnetic nanoparticles facilitate the cancer cell targeting with an external magnetic field located near the tumor site. This carrier was characterized by techniques such as FT-IR, 1H-NMR, UV-Vis, DLS, TGA, TEM, zeta potential, WAXD and VSM. Moreover, in vitro drug release profiles and cytotoxicity assays were investigated.

Graphical abstract: Dendritic magnetite decorated by pH-responsive PEGylated starch: a smart multifunctional nanocarrier for the triggered release of anti-cancer drugs

Article information

Article type
Paper
Submitted
06 Mar 2015
Accepted
11 May 2015
First published
01 Jun 2015

RSC Adv., 2015,5, 48586-48595

Dendritic magnetite decorated by pH-responsive PEGylated starch: a smart multifunctional nanocarrier for the triggered release of anti-cancer drugs

A. Pourjavadi, Z. M. Tehrani and S. H. Hosseini, RSC Adv., 2015, 5, 48586 DOI: 10.1039/C5RA04040J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements