Issue 33, 2015

Copper(i)/Lewis acid triggered ring-opening coupling reaction of cyclopropenes with nitriles

Abstract

A ring-opening coupling reaction of D–A cyclopropenes and nitriles is described for the facile synthesis of γ-amino ketones. The co-catalytic system combining copper(I) and boron trifluoride would be inspiring because it disfavors the [3 + 2] cycloaddition to turn the selectivity over the Ritter process.

Graphical abstract: Copper(i)/Lewis acid triggered ring-opening coupling reaction of cyclopropenes with nitriles

Supplementary files

Article information

Article type
Communication
Submitted
26 Jan 2015
Accepted
02 Mar 2015
First published
02 Mar 2015

RSC Adv., 2015,5, 26335-26338

Author version available

Copper(I)/Lewis acid triggered ring-opening coupling reaction of cyclopropenes with nitriles

H. Huang, X. Ji, F. Xiao and G. Deng, RSC Adv., 2015, 5, 26335 DOI: 10.1039/C5RA01541C

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