Issue 33, 2015
From the journal:

RSC Advances

Copper(i)/Lewis acid triggered ring-opening coupling reaction of cyclopropenes with nitriles†

Huawen Huang,*a   Xiaochen Ji,a   Fuhong Xiaoa  and  Guo-Jun Deng*a  

* Corresponding authors

a Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China
E-mail: hwhuang@xtu.edu.cn, gjdeng@xtu.edu.cn

Abstract

A ring-opening coupling reaction of D–A cyclopropenes and nitriles is described for the facile synthesis of γ-amino ketones. The co-catalytic system combining copper(I) and boron trifluoride would be inspiring because it disfavors the [3 + 2] cycloaddition to turn the selectivity over the Ritter process.

Graphical abstract: Copper(i)/Lewis acid triggered ring-opening coupling reaction of cyclopropenes with nitriles

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Article information

DOI
https://doi.org/10.1039/C5RA01541C
Article type
Communication
Submitted
26 Jan 2015
Accepted
02 Mar 2015
First published
02 Mar 2015

RSC Adv., 2015,5, 26335-26338

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Copper(I)/Lewis acid triggered ring-opening coupling reaction of cyclopropenes with nitriles

H. Huang, X. Ji, F. Xiao and G. Deng, RSC Adv., 2015, 5, 26335 DOI: 10.1039/C5RA01541C

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