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Issue 37, 2015
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Co–salen complexes as catalysts for the asymmetric Henry reaction – reversed enantioselectivity through simple ligand modification

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Abstract

The asymmetric Henry reaction is an efficient method for the synthesis of enantioenriched nitro alcohols. We investigated the catalytic activity and enantioselectivity of derivatives of Co–salen [salen = N,N′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamine] in this reaction. Tetrahydro-salen (salan) complexes displayed a reversed enantioselectivity compared to their Schiff-base counterparts. Oligomeric Co–salen catalysts showed a higher activity than their small molecule analogues, indicating a bimetallic pathway.

Graphical abstract: Co–salen complexes as catalysts for the asymmetric Henry reaction – reversed enantioselectivity through simple ligand modification

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Publication details

The article was received on 23 Dec 2014, accepted on 16 Mar 2015 and first published on 26 Mar 2015


Article type: Paper
DOI: 10.1039/C4RA16931J
Citation: RSC Adv., 2015,5, 29108-29113
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    Co–salen complexes as catalysts for the asymmetric Henry reaction – reversed enantioselectivity through simple ligand modification

    J. Dimroth and M. Weck, RSC Adv., 2015, 5, 29108
    DOI: 10.1039/C4RA16931J

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