Jump to main content
Jump to site search

Issue 16, 2015
Previous Article Next Article

Enantiomeric neolignans and sesquineolignans from Jatropha integerrima and their absolute configurations

Author affiliations

Abstract

Two pairs of new sesquineolignan enantiomers, (±)-jatrointelignans A and B (1a/1b and 2a/2b), one pair of new neolignan enantiomers, (±)-jatrointelignan D (4a/4b), and two new neolignans, (+)-jatrointelignan C (3a), and (+)-schisphenlignan I (5a) together with seven known analogues (3b, 5b, 6a, 6b, 7a, 7b, and 8) were isolated from the trunks of Jatropha integerrima. The structures were determined by combined spectroscopic and chemical methods, and their absolute configurations were elucidated by the circular dichroism (CD) method, in particular the configurations of the aryl glycerol-7′′,8′′-yloxy moiety in 1 and 2 were determined via the Rh2(OCOCF3)4-induced CD analysis. All compounds were examined for their inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in BV-2 microglial cells, and compounds 5a, 6a, and 4b exhibited pronounced inhibition on NO production with IC50 values in the range of 5.9–8.9 μM, being more active than the positive control, quercetin (IC50 = 17.0 μM).

Graphical abstract: Enantiomeric neolignans and sesquineolignans from Jatropha integerrima and their absolute configurations

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Dec 2014, accepted on 13 Jan 2015 and first published on 14 Jan 2015


Article type: Paper
DOI: 10.1039/C4RA15966G
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 12202-12208
  •   Request permissions

    Enantiomeric neolignans and sesquineolignans from Jatropha integerrima and their absolute configurations

    J. Zhu, B. Cheng, Y. Zheng, Z. Dong, S. Lin, G. Tang, Q. Gu and S. Yin, RSC Adv., 2015, 5, 12202
    DOI: 10.1039/C4RA15966G

Search articles by author

Spotlight

Advertisements