Issue 11, 2015
From the journal:

RSC Advances

The aqueous medium-dimethylsulfoxide conundrum in biological studies

Saeedeh Negin,ab   Michael R. Gokel,a   Mohit B. Patel,bc   Sergey L. Sedinkin,ab   David C. Osborna  and  George W. Gokel*abc  

* Corresponding authors

a Center for Nanoscience, University of Missouri-St. Louis, St. Louis, Missouri, USA
E-mail: gokelg@umsl.edu
Fax: +1-314-516-5342
Tel: +1-314-516-5321

b Dept. of Chemistry, University of Missouri-St. Louis, St. Louis, Missouri, USA

c Department of Biology, University of Missouri-St. Louis, St. Louis, Missouri, USA

Abstract

A series of straight and branched chain pyrogallol[4]arenes was studied and found to be essentially nontoxic to two strains of E. coli. An apparent enhancement of potency observed for kanamycin against E. coli was found to be due to the presence of DMSO in the growth media. Quantitative studies are presented that assay the effect of DMSO concentration on the apparent potency of kanamycin against E. coli.

Graphical abstract: The aqueous medium-dimethylsulfoxide conundrum in biological studies

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Article information

DOI
https://doi.org/10.1039/C4RA15217D
Article type
Paper
Submitted
25 Nov 2014
Accepted
15 Dec 2014
First published
15 Dec 2014

RSC Adv., 2015,5, 8088-8093

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The aqueous medium-dimethylsulfoxide conundrum in biological studies

S. Negin, M. R. Gokel, M. B. Patel, S. L. Sedinkin, D. C. Osborn and G. W. Gokel, RSC Adv., 2015, 5, 8088 DOI: 10.1039/C4RA15217D

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