Issue 17, 2015
From the journal:

RSC Advances

New bioactive steroids from the soft coral Klyxum flaccidum†

Chia-Ruei Tsai,a   Chiung-Yao Huang,a   Bo-Wei Chen,a   Yi-Ying Tsai,a   Shou-Ping Shih,b   Tsong-Long Hwang,c   Chang-Feng Dai,d   Sheng-Yang Wange  and  Jyh-Horng Sheu*afg  

* Corresponding authors

a Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
E-mail: sheu@mail.nsysu.edu.tw
Fax: +886-7-525-5020
Tel: +886-7-525-2000 ext. 5030

b Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan

c Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan

d Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan

e Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan

f Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan

g Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan

Abstract

Six new steroids, klyflaccisteroids A–E (1–5) and a new 9,11-secogorgosteroid klyflaccisteroid F (6), along with two known steroids 9,11-secosteroid 3β,11-dihydroxy-9,11-secogorgost-5-en-9-one (7) and gorgost-5-ene-3β,9α,11α-triol (8), and a known eunicellin-based diterpenoid cladiellisin (9), were discovered from the soft coral K. flaccidum. Compound 6 is the first 9,11-secogorgosteroid 11-carboxylic acid isolated from natural sources. Cytotoxicity of these compounds and anti-inflammatory activities of 1–4 and 6–9 were also evaluated. Some compounds were shown to exhibit attractive bioactivities.

Graphical abstract: New bioactive steroids from the soft coral Klyxum flaccidum

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Article information

DOI
https://doi.org/10.1039/C4RA13977A
Article type
Paper
Submitted
06 Nov 2014
Accepted
12 Jan 2015
First published
28 Jan 2015

RSC Adv., 2015,5, 12546-12554

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New bioactive steroids from the soft coral Klyxum flaccidum

C. Tsai, C. Huang, B. Chen, Y. Tsai, S. Shih, T. Hwang, C. Dai, S. Wang and J. Sheu, RSC Adv., 2015, 5, 12546 DOI: 10.1039/C4RA13977A

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