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Issue 14, 2015
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Development of a highly efficient single-mode microwave applicator with a resonant cavity and its application to continuous flow syntheses

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Abstract

Microwave-assisted organic synthesis has many advantages and is widely applied to a variety of reactions. We have developed a new single-mode microwave applicator, specific to continuous flow synthesis, whose main feature is that it generates a uniform electromagnetic field inside its resonant cavity. Two well-known reactions, the Fischer indole synthesis and the Diels–Alder reaction, proceeded very quickly when a solution of substrates was pumped through a helical glass tube reactor inside the resonant cavity, under a pressure of 2.5 MPa. The desired products were obtained in high yields. This compact apparatus constitutes a new method for switching organic synthesis from batch to continuous flow, and enables continuous synthesis of products at a scale of 100 g h−1 or more.

Graphical abstract: Development of a highly efficient single-mode microwave applicator with a resonant cavity and its application to continuous flow syntheses

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Publication details

The article was received on 15 Oct 2014, accepted on 05 Jan 2015 and first published on 06 Jan 2015


Article type: Paper
DOI: 10.1039/C4RA12428F
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 10204-10210
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    Development of a highly efficient single-mode microwave applicator with a resonant cavity and its application to continuous flow syntheses

    S. Yokozawa, N. Ohneda, K. Muramatsu, T. Okamoto, H. Odajima, T. Ikawa, J. Sugiyama, M. Fujita, T. Sawairi, H. Egami, Y. Hamashima, M. Egi and S. Akai, RSC Adv., 2015, 5, 10204
    DOI: 10.1039/C4RA12428F

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