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Issue 10, 2015
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Enantioselective nickel-catalyzed alkylative alkyne–aldehyde cross-couplings

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Abstract

An efficient asymmetric nickel-catalyzed alkylative alkyne–aldehyde cross-coupling is developed by employing a P-chiral monophosphorus ligand BI-DIME, allowing rapid access to a series of chiral tetra-substituted olefinic allylic alcohols in high yields and good to excellent ees. The three-component reactions enjoy excellent regio- and enantioselectivities, and a broad substrate scope from readily available starting materials.

Graphical abstract: Enantioselective nickel-catalyzed alkylative alkyne–aldehyde cross-couplings

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Publication details

The article was received on 04 May 2015, accepted on 22 Jul 2015 and first published on 23 Jul 2015


Article type: Research Article
DOI: 10.1039/C5QO00148J
Author version available: Download Author version (PDF)
Citation: Org. Chem. Front., 2015,2, 1322-1325
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    Enantioselective nickel-catalyzed alkylative alkyne–aldehyde cross-couplings

    M. Nie, W. Fu, Z. Cao and W. Tang, Org. Chem. Front., 2015, 2, 1322
    DOI: 10.1039/C5QO00148J

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