Issue 8, 2015

I2-catalyzed one-pot synthesis of pyrrolo[1,2-a]quinoxaline and imidazo[1,5-a]quinoxaline derivatives via sp3 and sp2 C–H cross-dehydrogenative coupling

Abstract

An efficient I2-catalyzed cascade coupling protocol was developed for the synthesis of pyrrolo[1,2-a]quinoxaline and imidazo[1,5-a]quinoxaline derivatives via sp3 and sp2 C–H cross-dehydrogenative coupling. A nontoxic, readily available catalyst, I2, and an oxidant, DMSO, were used in this metal-free process. The target compounds were obtained in good-to-excellent yields with a broad substrate scope.

Graphical abstract: I2-catalyzed one-pot synthesis of pyrrolo[1,2-a]quinoxaline and imidazo[1,5-a]quinoxaline derivatives via sp3 and sp2 C–H cross-dehydrogenative coupling

Supplementary files

Article information

Article type
Research Article
Submitted
14 Apr 2015
Accepted
02 Jun 2015
First published
03 Jun 2015

Org. Chem. Front., 2015,2, 942-946

I2-catalyzed one-pot synthesis of pyrrolo[1,2-a]quinoxaline and imidazo[1,5-a]quinoxaline derivatives via sp3 and sp2 C–H cross-dehydrogenative coupling

Z. Zhang, C. Xie, X. Tan, G. Song, L. Wen, H. Gao and C. Ma, Org. Chem. Front., 2015, 2, 942 DOI: 10.1039/C5QO00124B

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