Issue 48, 2015
From the journal:

Polymer Chemistry

An injectable drug-loaded hydrogel using a “clickable” amphiphilic triblock copolymer as a precursor†

Lilong Gao,‡a   Guangyu Zha,‡b   Ying Wang,ab   Qiaojie Luo,b   Weipu Zhu,*a   Zhiquan Shena  and  Xiaodong Li*b  

* Corresponding authors

a MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: zhuwp@zju.edu.cn

b Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310068, P. R. China
E-mail: cisarli@zju.edu.cn

Abstract

We developed a facile strategy to prepare an injectable drug-loaded hydrogel with chemical crosslinkages. A PCL-POEGM-PCL amphiphilic triblock copolymer was synthesized in “one pot” by a combination of polycondensation and ring-opening polymerization, which can disperse hydrophobic drugs in aqueous solution and be crosslinked by POEGMS under physiological conditions.

Graphical abstract: An injectable drug-loaded hydrogel using a “clickable” amphiphilic triblock copolymer as a precursor

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Article information

DOI
https://doi.org/10.1039/C5PY01383F
Article type
Communication
Submitted
29 Aug 2015
Accepted
21 Sep 2015
First published
24 Sep 2015

Polym. Chem., 2015,6, 8240-8243

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An injectable drug-loaded hydrogel using a “clickable” amphiphilic triblock copolymer as a precursor

L. Gao, G. Zha, Y. Wang, Q. Luo, W. Zhu, Z. Shen and X. Li, Polym. Chem., 2015, 6, 8240 DOI: 10.1039/C5PY01383F

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