Issue 40, 2015
From the journal:

Polymer Chemistry

Sustained drug release from an ultrathin hydrogel film†

Weipu Zhu,a   Lu Xiong,a   Huan Wang,a   Guangyu Zha,b   Hong Du,a   Xiaodong Li*b  and  Zhiquan Shena  

* Corresponding authors

a MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: zhuwp@zju.edu.cn
Fax: +86 571 87953727
Tel: +86 571 87953739

b Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, P. R. China
E-mail: cisarli@zju.edu.cn
Fax: +86 571 87217430
Tel: +86 571 87217430

Abstract

We reported a facile method to prepare camptothecin (CPT) loaded ultrathin hydrogel films based on a polymeric prodrug via layer by layer (LbL) thiol–ene “click” chemistry. Free camptothecin could be sustainedly released from the ultrathin hydrogel film within 24 hours through the hydrolysis of ester bonds between the hydrogel backbone and the camptothecin moieties.

Graphical abstract: Sustained drug release from an ultrathin hydrogel film

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Article information

DOI
https://doi.org/10.1039/C5PY01204J
Article type
Communication
Submitted
31 Jul 2015
Accepted
24 Aug 2015
First published
26 Aug 2015

Polym. Chem., 2015,6, 7097-7099

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Sustained drug release from an ultrathin hydrogel film

W. Zhu, L. Xiong, H. Wang, G. Zha, H. Du, X. Li and Z. Shen, Polym. Chem., 2015, 6, 7097 DOI: 10.1039/C5PY01204J

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