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Issue 31, 2015
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Glyconanoparticles and their interactions with lectins

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Abstract

Recent progress in nanobiotechnology has allowed the use of glycans and their conjugates as biofunctional molecules for many biological and biomedical applications. Therefore, specific interactions of carbohydrate-binding proteins (lectins) are continuously being elucidated for a deep understanding of their functions and the precise mechanism of their association with specific ligands. New generations of glyconanoparticles with outstanding features that present carbohydrates in a multivalent manner and locally in high concentrations have been showing promise of establishing the glycan code and functioning as a glycan mimic. In the first part of this review article, different types of lectins have been summarised and their main properties highlighted. In the second part, recent successful examples of glyconanoparticles formed of synthetic polymers and in most cases, conjugated with metals, have been discussed in terms of their synthesis and interactions with lectins.

Graphical abstract: Glyconanoparticles and their interactions with lectins

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Publication details

The article was received on 21 Jan 2015, accepted on 26 Feb 2015 and first published on 02 Mar 2015


Article type: Review Article
DOI: 10.1039/C5PY00089K
Citation: Polym. Chem., 2015,6, 5503-5514
  • Open access: Creative Commons BY license
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    Glyconanoparticles and their interactions with lectins

    G. Yilmaz and C. R. Becer, Polym. Chem., 2015, 6, 5503
    DOI: 10.1039/C5PY00089K

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