Issue 15, 2015

Porphyrin-containing amphiphilic block copolymers for photodynamic therapy

Abstract

Amphiphilic PNIPAM-b-PTPPC6MA block copolymers were first synthesized using porphyrin-containing monomers. The mono-hydroxylphenyl-triphenylporphyrin photosensitizer, TPP-OH, was modified into a porphyrin monomer, and it was further used to construct the amphiphilic PNIPAM-b-PTPPC6MA block copolymers using RAFT polymerization. PNIPAM-b-PTPPC6MA block copolymers can self-assemble into a plethora of morphologies ranging from spheres to vesicular aggregates and further to a single large vesicle. The PNIPAM-b-PTPPC6MA micelles exhibited a high singlet oxygen quantum yield. Moreover, confocal laser scanning microscopy (CLSM) and flow cytometry analysis confirmed that PNIPAM-b-PTPPC6MA micelles could effectively enhance the internalization rate in MCF-7 cells. According to the MTT assay, PNIPAM-b-PTPPC6MA micelles exhibited low dark toxicity and efficient PDT efficacy towards MCF-7 cells. Thus PNIPAM-b-PTPPC6MA block copolymers have the potential application for photodynamic therapy.

Graphical abstract: Porphyrin-containing amphiphilic block copolymers for photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
12 Jan 2015
Accepted
23 Feb 2015
First published
25 Feb 2015

Polym. Chem., 2015,6, 2945-2954

Author version available

Porphyrin-containing amphiphilic block copolymers for photodynamic therapy

L. Xu, L. Liu, F. Liu, H. Cai and W. Zhang, Polym. Chem., 2015, 6, 2945 DOI: 10.1039/C5PY00039D

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