Jump to main content
Jump to site search

Issue 11, 2015
Previous Article Next Article

A robust platform for functional microgels via thiol–ene chemistry with reactive polyether-based nanoparticles

Author affiliations

Abstract

We herein report the development of crosslinked polyether particles as a reactive platform for the preparation of functional microgels. Thiol–ene crosslinking of poly(allyl glycidyl ether) in miniemulsion droplets – stabilized by a surface active, bio-compatible polyethylene glycol block copolymer – resulted in colloidal gels with a PEG corona and an inner polymeric network containing reactive allyl units. The stability of the allyl groups allows the microgels to be purified and stored before a second, subsequent thiol–ene functionalization step allows a wide variety of pH- and chemically-responsive groups to be introduced into the nanoparticles. The facile nature of this synthetic platform enables the preparation of microgel libraries that are responsive to different triggers but are characterized by the same size distribution, surface functionality, and crosslinking density. In addition, the utilization of a crosslinker containing cleavable ester groups renders the resulting hydrogel particles degradable at elevated pH or in the presence of esterase under physiological conditions.

Graphical abstract: A robust platform for functional microgels via thiol–ene chemistry with reactive polyether-based nanoparticles

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Dec 2014, accepted on 06 Jan 2015 and first published on 14 Jan 2015


Article type: Paper
DOI: 10.1039/C4PY01766H
Citation: Polym. Chem., 2015,6, 2029-2037
  •   Request permissions

    A robust platform for functional microgels via thiol–ene chemistry with reactive polyether-based nanoparticles

    C. Fleischmann, J. Gopez, P. Lundberg, H. Ritter, K. L. Killops, C. J. Hawker and D. Klinger, Polym. Chem., 2015, 6, 2029
    DOI: 10.1039/C4PY01766H

Search articles by author

Spotlight

Advertisements