Issue 46, 2015
From the journal:

Organic & Biomolecular Chemistry

N-Heterocyclic carbene-catalyzed [3 + 3] cyclocondensation of bromoenals with hydrazones: highly enantioselective synthesis of dihydropyridazones†

Chun-Lin Zhang,a   Dong-Ling Wang,a   Kun-Quan Chena  and  Song Ye*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: songye@iccas.ac.cn

Abstract

The N-heterocyclic carbene-catalyzed [3 + 3] cyclocondensation of bromoenals and hydrazones is developed to give the corresponding chiral 4,5-dihydropyridazones in good yields with excellent enantioselectivities.

Graphical abstract: N-Heterocyclic carbene-catalyzed [3 + 3] cyclocondensation of bromoenals with hydrazones: highly enantioselective synthesis of dihydropyridazones

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Article information

DOI
https://doi.org/10.1039/C5OB01748C
Article type
Paper
Submitted
21 Aug 2015
Accepted
16 Sep 2015
First published
17 Sep 2015

Org. Biomol. Chem., 2015,13, 11255-11262

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N-Heterocyclic carbene-catalyzed [3 + 3] cyclocondensation of bromoenals with hydrazones: highly enantioselective synthesis of dihydropyridazones

C. Zhang, D. Wang, K. Chen and S. Ye, Org. Biomol. Chem., 2015, 13, 11255 DOI: 10.1039/C5OB01748C

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